Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents
نویسندگان
چکیده
In this work, a racemization method of (S)-1-phenylethanol by niobium salts was developed. Among the available, phosphate hydrate (NbOPO4.nH2O) reduced enantiomeric excess (ee) chiral alcohol from 95 to 0% after 24 h at 60 ºC in toluene. This new agent combined with lipase (CALB) order achieve chemoenzymatic dynamic kinetic resolution (DKR). Experiments demonstrated that DKR process is feasible and corresponding (R)-1-phenylethyl acetate obtained 92% conversion 85% ee.
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2021
ISSN: ['0103-5053', '1678-4790']
DOI: https://doi.org/10.21577/0103-5053.20210086